Anidulafungin and its role in candida infections

Anidulafungin and its role in candida infections

Candida infections continue to play a significant role not only in critically ill and immunocompromised patients but also in non-compromised patients. The incidence of systemic fungal infections in the United States has been on the rise for the past 30 years. Anidulafungin and all echinocandins inhibit glucan synthase thus inhibiting the formation of 1,3-β-D-glucan which is an essential compone...

Anidulafungin (Eraxis) for Fungal Infections

INTRODUCTION Over the last 25 years, the incidence of fungal infections has increased dramatically. Predominantly a nosocomial complication, invasive fungal infections are growing in the expanding population of at-risk hospitalized patients. The greatest risk lies in the ever-increasing number of immunocompromised patients, including patients with human immunodeficiency virus (HIV) infection an...

Anidulafungin for Candida glabrata infective endocarditis.

Hwp1 gene Expression of Candida albicans and Study its role in adherence

Candida albicans is an opportunistic fungal pathogen found as mycoflora in the human body surfaces. Sevral genes play a crucial rule in its virulence including Hwp1 (hyphal wall protein 1), BCR1 and ALS gene family. Hwp1 gene is a responsible for coding a cell surface protein, which mediates biofilm formation in candida albicans. Here we investigated the presence of the HWP1gene was characteris...

Anidulafungin: an evidence-based review of its use in invasive fungal infections

INTRODUCTION Anidulafungin is a new echinocandin antifungal agent with indications for use in esophageal candidiasis and candidemia. The mortality and morbidity associated with fungal infections in healthcare facilities necessitates the development of new treatment options for these diseases. AIMS This review assesses the pharmacology and evidence for the use of anidulafungin in the treatment...